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If coadministration is unavoidable, monitor sufferers for lack of therapeutic impact of those medicine. Fexinidazole will enhance the extent or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Fexinidazole inhibits CYP3A4. Coadministration could increase risk for adverse effects of CYP3A4 substrates. Esketamine intranasal, modafinil.